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Innovation in care

Boehringer Ingelheim is a research-driven group of companies dedicated to the discovery, development, manufacture and marketing of innovative health care products

Holistic Cardio-Renal-Metabolic care

Integrated management across interconnected risks

Why it matters:
  • The burden of cardiovascular disease and CKD remains high in T2DM patients
  • Delayed recognition of interconnected risks can lead to increased complications and mortality
  • Early, integrated intervention across CV, renal, and metabolic domains is essential
  • A holistic strategy enables better risk reduction and long-term patient outcomes
cardio renal metabolic risk management int2dm

Original research product

Bioequivalence and therapeutic equivalence are not similar8,9

Original research product

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JARDIANCE®: A 4-time Prix-Galien award winner
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Abbreviations: CKD, chronic kidney disease; CRM, cardio-renal-metabolic; CV, cardiovascular; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HF, heart failure; T2DM, type 2 diabetes mellitus.

  1. Anjana RM, Unnikrishnan R, Mugilan P, et al. Causes and predictors of mortality in Asian Indians with and without diabetes-10-year follow-up of the Chennai Urban Rural Epidemiology Study (CURES - 150). PLoS One. 2018;13(7):e0197376.

  2. Unnikrishnan AG, Sahay RK, Phadke U, et al. Cardiovascular risk in newly diagnosed type 2 diabetes patients in India. PLoS One. 2022;17(3):e0263619.

  3. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395(10225):709-733.

  4. Xie Y, Bowe B, Mokdad AH, et al. Analysis of the global burden of disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016. Kidney Int. 2018;94(3):567-581.

  5. Ene-Iordache B, Perico N, Bikbov B, et al. Chronic kidney disease and cardiovascular risk in six regions of the world (ISN-KDDC): a cross-sectional study. Lancet Glob Health. 2016;4(5):e307-e319.

  6. India state-level disease burden initiative CVD collaborators. The changing patterns of cardiovascular diseases and their risk factors in the states of India: The global burden of disease study 1990-2016. Lancet Glob Health. 2018;6(12):e1339-e1351.

  7. Johansson Bartolini I, Joseph P, Islam S, et al. Heart Failure Among 173,000 Community-Dwelling Participants From 25 Low-, Middle-, and High-Income Countries in the PURE Study. J Am Coll Cardiol. Published online April 22, 2026.

  8. Roy V, Rana P. Prescribing generics: All in a name. Indian J Med Res. 2018;147(5):442-444.

  9. Chow SC. Bioavailability and bioequivalence in drug development. Wiley Interdiscip Rev Comput Stat. 2014;6(4):304-312.

  10. Zou L, Ni Z, Tsakalozou E, Giacomini KM. Impact of pharmaceutical excipients on oral drug absorption: A focus on intestinal drug transporters. Clin Pharmacol Ther. 2019;105(2):323-325. 

  11. Subramaniam S, Kamath S, Ariaee A, Prestidge C, Joyce P. The impact of common pharmaceutical excipients on the gut microbiota. Expert Opin Drug Deliv. 2023;20(10):1297-1314.

  12. Martinez MN, Sinko B, Wu F, et al. A critical overview of the biological effects of excipients (part I): Impact on gastrointestinal absorption. AAPS J. 2022;24(3):60.

  13. Patel R, Barker J, ElShaer A. Pharmaceutical excipients and drug metabolism: A mini-review. Int J Mol Sci. 2020;21(21):8224.

  14. Martinez MN, Wu F, Sinko B, et al. A critical overview of the biological effects of excipients (part ii): scientific considerations and tools for oral product development. AAPS J. 2022;24(3):61.

  15. Abrantes CG, Duarte D, Reis CP. An overview of pharmaceutical excipients: safe or not safe?. J Pharm Sci. 2016;105(7):2019-2026.

  16. Comoglu T, Ozyilmaz ED. Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives. Pharm Dev Technol. 2025;30(1):1-9.

  17. Noh IJ, Gray J, Ball G, et al. Are all generic drugs created equal? An empirical analysis of generic drug manufacturing location and serious adverse events. Prod Oper Manag. 2025;34(9):2601-2617.

  18. The Galien Foundation. Laureates Private Sector Since 1970. Accessed February 22, 2025. Available at: https://www.galienfoundation.org/laureates-worldwide

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